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Quantification of In Vivo Metabolic Activity of CYP2D6 Genotypes and Alleles Through Population Pharmacokinetic Analysis of Vortioxetine.

Clinical pharmacology and therapeutics - 1 Jan 2021

Frederiksen Trine, Areberg Johan, Schmidt Ellen, Bjerregaard Stage Tore, Brøsen Kim

Abstract excerpt

Assignment of CYP2D6 phenotype from genotype data can be challenging and despite efforts to standardize translation, there is currently no universally accepted method. To facilitate standardization, there remains a need to precisely quantify the in vivo function of different CYP2D6 genotypes. Vortioxetine is metabolized to its major metabolite, Lu AA34443, primarily via CYP2D6. The aim of this study was to...

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Adolescent
Aged
Alleles
Child
Cytochrome P-450 CYP2D6

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PMID: 32599653
DOI: 10.1002/cpt.1972
PMCID: PMC7818194

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