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Article

The CYP2A subfamily: function, expression and genetic polymorphism.

IARC scientific publications - 1 Jan 1999

Raunio H, Rautio A, Pelkonen O

Abstract excerpt

The CYP2A6 gene is one of the three members of the human CYP2A gene subfamily, the others being CYP2A7 and CYP2A13. The CYP2A6 enzyme catalyses the oxidation of several compounds that have clinical or toxicological interest, including pharmaceuticals, procarcinogens, and tobacco smoke constituents. CYP2A6 is expressed mainly in liver, and only trace amounts are found in extrahepatic tissues. Coumarin is a...

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PMID: 10493259

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