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Drug metabolizing enzyme activities versus genetic variances for drug of clinical pharmacogenomic relevance

28 Jul 2011

Abstract excerpt

Enzymes are critically important in the transportation, metabolism, and clearance of most therapeutic drugs used in clinical practice today. Many of these enzymes have significant genetic polymorphisms that affect the enzyme's rate kinetics. Regarding drug metabolism, specific polymorphisms to the cytochrome (CYP) P450 enzyme family are linked to phenotypes that describe reaction rates as "ultra", "intermediate",...

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PMID: 21906384
DOI: 10.1186/1559-0275-8-12

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