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Article

Inter-individual Variability in Activity of the Major Drug Metabolizing Enzymes in Liver Homogenates of 20 Individuals.

Current drug metabolism - 1 Jan 2018

den Braver-Sewradj Shalenie P, den Braver Michiel W, van Dijk Marc, Zhang Yongjie, Dekker Stefan J, Wijaya Lukas, Vermeulen Nico P E, Richert Lysiane, Commandeur Jan N M, Vos J Chris

Abstract excerpt

BACKGROUND: Inter-individual variability in hepatic drug metabolizing enzyme (DME) activity is a major contributor to heterogeneity in drug clearance and safety. Accurate data on expression levels and activities of DMEs is an important prerequisite for in vitro-in vivo extrapolation and in silico based predictions. Characterization and assessment of inter-correlations of the major DMEs cytochrome P450s (CYPs) and...

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Source

Identifiers

PMID: 29318967
DOI: 10.2174/1389200219666180108160046

Genes

NQO1
NQO2
GSTM3
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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