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Article

Impact of POR and cytochrome b5 variability on the genotype-phenotype discordance of CYP2A6 and CYP2D6: A quantitative analysis in Chinese human livers.

Drug metabolism and disposition: the biological fate of chemicals - 1 Apr 2026

Fang Yan, Wang Jiyao, Liu Demeng, Li Junle, Tian Xin, Gao Na, Zhang Haifeng, Wen Qiang, Qiao Hailing

Abstract excerpt

Genotyping of CYP2A6 and CYP2D6 is a cornerstone of personalized medicine; however, current dosing algorithms often assume distinct phenotypic clusters, overlooking the substantial phenotypic overlap among genotypes. This study aimed to quantify genotype-phenotype concordance and identify the mechanistic determinants of prediction discrepancies. Using 90 Chinese human liver specimens, we evaluated CYP2A6 (alleles...

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Cytochrome P-450 CYP2A6
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
Cytochromes b5
East Asian People

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microsomes, Liver

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Identifiers

PMID: 41955878
DOI: 10.1016/j.dmd.2026.100264

Genes

CYP2A6
POR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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