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Article

SIRT2 deficiency prevents age-related bone loss in rats by inhibiting osteoclastogenesis

30 Sept 2019

Abstract excerpt

Sirtuin 2 (SIRT2) is a deacetylase that belongs to class III family of histone deacetylases (HDACs). Although it is the most abundantly expressed member of HDAC-III in human bone tissues, it is unclear whether SIRT2 plays a role in bone metabolism. In this study, the role of SIRT2 in bone metabolism, and the underlying mechanism were investigated. In in vivo experiments, micro-CT analysis revealed that there were...

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PMID: 31880520
DOI: 10.14715/cmb/2019.65.7.12

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