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Article

Phenotypic research on senile osteoporosis caused by SIRT6 deficiency.

International journal of oral science - 30 Jun 2016

Zhang De-Mao, Cui Di-Xin, Xu Ruo-Shi, Zhou Ya-Chuan, Zheng Li-Wei, Liu Peng, Zhou Xue-Dong

Abstract excerpt

Osteoporosis is a serious public bone metabolic disease. However, the mechanisms underlying bone loss combined with ageing, which is known as senile osteoporosis, remains unknown. Here we show the detailed phenotype of this disease caused by SIRT6 knock out (KO) in mice. To the best of our knowledge, this is the first study to reveal that SIRT6 is expressed in both bone marrow stroma cells and bone-related cells...

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Source

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Identifiers

PMID: 27357320
DOI: 10.1038/ijos.2015.57
PMCID: PMC4932771

Genes

SIRT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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