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Impaired autophagy triggered by HDAC9 in mesenchymal stem cells accelerates bone mass loss

3 Jul 2020

Abstract excerpt

BACKGROUND: Bone mass loss in aging is linked with imbalanced lineage differentiation of bone marrow mesenchymal stem cells (BMMSCs). Recent studies have proved that histone deacetylases (HDACs) are regarded as key regulators of bone remodeling. However, HDACs involve in regulating BMMSC bio-behaviors remain elusive. Here, we investigated the ability of HDAC9 on modulation of autophagy and its significance in...

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Share to Autophagy in Disease and Therapy
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PMID: 32620134
DOI: 10.1186/s13287-020-01785-6

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