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Article

SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis.

PloS one - 1 Jan 2017

Zainabadi Kayvan, Liu Cassie J, Caldwell Alison L M, Guarente Leonard

Abstract excerpt

Overexpression or pharmacological activation of SIRT1 has been shown to extend the lifespan of mice and protect against aging-related diseases. Here we show that pharmacological activation of SIRT1 protects in two models of osteoporosis. Ovariectomized female mice and aged male mice, models for post-menopausal and aging-related osteoporosis, respectively, show significant improvements in bone mass upon treatment...

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Source

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Identifiers

PMID: 28937996
DOI: 10.1371/journal.pone.0185236
PMCID: PMC5609767

Genes

SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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