Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus

3 Mar 2025

Abstract excerpt

Osteoporosis represents a prevalent and debilitating comorbidity in patients diagnosed with type 2 diabetes mellitus (T2DM), which is characterized by suppressed osteoblast function and disrupted bone microarchitecture. In this study, we utilized male C57BL/6 J mice to investigate the role of SIRT3 in T2DM. Decreased SIRT3 expression and impaired mitochondrial quality control mechanism are observed in both in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Mitochondrial Function and Pathology
Share to Sirtuins and Resveratrol in Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40025004
DOI: 10.1038/s41413-024-00399-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitusPMID 40025004Read ↗

Sirtuins mediate mitochondrial quality control mechanisms: a novel therapeutic target for osteoporosisSemantic proximity Read ↗

Sirt3 deficiency exacerbates diabetic cardiac dysfunction: Role of Foxo3A-Parkin-mediated mitophagySemantic proximity Read ↗

Sirtuins and Type 2 Diabetes: Role in Inflammation, Oxidative Stress, and Mitochondrial FunctionSemantic proximity Read ↗

Sirtuin 3 deficiency exacerbates age‐related periodontal diseaseSemantic proximity Read ↗

Mst1 inhibits Sirt3 expression and contributes to diabetic cardiomyopathy through inhibiting Parkin-dependent mitophagySemantic proximity Read ↗

SIRT3 Regulation of Mitochondrial Quality Control in Neurodegenerative DiseasesSemantic proximity Read ↗

Insulin/IGF-1R, SIRT1, and FOXOs Pathways—An Intriguing Interaction Platform for Bone and OsteosarcomaSemantic proximity Read ↗

Activation of BK channels prevents diabetes-induced osteopenia by regulating mitochondrial Ca 2+ and SLC25A5/ANT2-PINK1-PRKN-mediated mitophagySemantic proximity Read ↗

SIRT3 regulates mitochondrial biogenesis in aging-related diseasesSemantic proximity Read ↗

PINK1 deficiency impairs osteoblast differentiation through aberrant mitochondrial homeostasisSemantic proximity Read ↗

The Role of FoxOs in Bone Health and Disease.Semantic proximity Read ↗

Sirtuins in osteoarthritis: current understandingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.