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Article

Sirtuin 3 deficiency exacerbates age‐related periodontal disease

30 Sept 2021

Abstract excerpt

Abstract Background Sirtuin 3 (SIRT3), a mitochondrial NAD+‐dependent deacetylase, has received much attention for its effect on metabolism and aging. However, the role of SIRT3 in periodontal disease remains unknown. Objective This study aimed to investigate the functional role of SIRT3 in age‐related periodontal disease and underlying mechanisms. Methods Sixteen mice were randomly assigned into four groups: the...

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PMID: 34591326
DOI: 10.1111/jre.12930

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