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Sirtuins in osteoarthritis: current understanding

17 Apr 2023

Abstract excerpt

Osteoarthritis (OA) is a common disease characterized by severe chronic joint pain, that imposes a large burden on elderly people. OA is a highly heterogeneous disease, and multiple etiologies contribute to its progression. Sirtuins (SIRTs) are Class III histone deacetylases (HDACs) that regulate a comprehensive range of biological processes such as gene expression, cell differentiation, and organism development,...

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PMID: 37138887
DOI: 10.3389/fimmu.2023.1140653

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