Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SIRT2 deacetylase represses NFAT transcription factor to maintain cardiac homeostasis

13 Feb 2018

Abstract excerpt

Heart failure is an aging-associated disease that is the leading cause of death worldwide. Sirtuin family members have been largely studied in the context of aging and aging-associated diseases. Sirtuin 2 (SIRT2) is a cytoplasmic protein in the family of sirtuins that are NAD + -dependent class III histone deacetylases. In this work, we studied the role of SIRT2 in regulating nuclear factor of activated T-cells...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine and Purinergic Signaling
Share to Signaling Pathways in Disease
Share to Sirtuins and Resveratrol in Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29440391
DOI: 10.1074/jbc.ra117.000915

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SIRT2 deacetylase represses NFAT transcription factor to maintain cardiac homeostasisPMID 29440391Read ↗

Targeting SIRT2 in Aging-Associated Fibrosis PathophysiologySemantic proximity Read ↗

SIRT2 Acts as a Cardioprotective Deacetylase in Pathological Cardiac Hypertrophy.Semantic proximity Read ↗

SIRT2 as a Therapeutic Target for Age-Related DisordersSemantic proximity Read ↗

The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-JunSemantic proximity Read ↗

Emerging beneficial roles of sirtuins in heart failureSemantic proximity Read ↗

Roles of sirtuin family members in chronic obstructive pulmonary diseaseSemantic proximity Read ↗

Cardioprotective Effects of SIRT6 in a Mouse Model of Transverse Aortic Constriction-Induced Heart FailureSemantic proximity Read ↗

Fibroblast growth factor 20 attenuates pathological cardiac hypertrophy by activating the SIRT1 signaling pathwaySemantic proximity Read ↗

The role of sirtuins in cardiac diseaseSemantic proximity Read ↗

Context-dependent role of sirtuin 2 in inflammationSemantic proximity Read ↗

SIRT2 regulates NF-κB-dependent gene expression through deacetylation of p65 Lys310Semantic proximity Read ↗

SIRT6 in Senescence and Aging-Related Cardiovascular DiseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.