Article
HLA and autoantibodies define scleroderma subtypes and risk in African and European Americans and suggest a role for molecular mimicry.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jan 2020
Gourh Pravitt, Safran Sarah A, Alexander Theresa, Boyden Steven E, Morgan Nadia D, Shah Ami A, Mayes Maureen D, Doumatey Ayo, Bentley Amy R, Shriner Daniel, Domsic Robyn T, Medsger Thomas A, Ramos Paula S, Silver Richard M, Steen Virginia D, Varga John, Hsu Vivien, Saketkoo Lesley Ann, Schiopu Elena, Khanna Dinesh, Gordon Jessica K, Kron Brynn, Criswell Lindsey A, Gladue Heather, Derk Chris T, Bernstein Elana J, Bridges S Louis, Shanmugam Victoria K, Kolstad Kathleen D, Chung Lorinda, Kafaja Suzanne, Jan Reem, Trojanowski Marcin, Goldberg Avram, Korman Benjamin D, Steinbach Peter J, Chandrasekharappa Settara C, Mullikin James C, Adeyemo Adebowale, Rotimi Charles, Wigley Fredrick M, Kastner Daniel L, Boin Francesco, Remmers Elaine F
Abstract excerpt
Systemic sclerosis (SSc) is a clinically heterogeneous autoimmune disease characterized by mutually exclusive autoantibodies directed against distinct nuclear antigens. We examined HLA associations in SSc and its autoantibody subsets in a large, newly recruited African American (AA) cohort and among European Americans (EA). In the AA population, the African ancestry-predominant HLA-DRB1*08:04 and HLA-DRB1*11:02...
Topics
- Black or African American
- Alleles
- Amino Acid Sequence
- Antigens, Viral
- Autoantibodies