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Contribution of HLA and KIR Alleles to Systemic Sclerosis Susceptibility and Immunological and Clinical Disease Subtypes

8 Jun 2022

Abstract excerpt

Systemic sclerosis (SSc) is an autoinflammatory, fibrotic condition of unknown aetiology. The presence of detectable autoantibodies against diverse nuclear antigens, as well as strong HLA associations with disease, suggest autoimmune involvement, however the links between endogenous and exogenous risk factors and SSc pathology remain undetermined. We have conducted a genetic analysis ofHLAinheritance in two...

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Share to Inflammatory Myopathies and Dermatomyositis
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PMID: 35754823
DOI: 10.3389/fgene.2022.913196

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