Comprehensive analysis of the major histocompatibility complex in systemic sclerosis identifies differential HLA associations by clinical and serological subtypes.

doi:10.1136/annrheumdis-2021-219884

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Article

Comprehensive analysis of the major histocompatibility complex in systemic sclerosis identifies differential HLA associations by clinical and serological subtypes.

Annals of the rheumatic diseases - 1 Aug 2021

Acosta-Herrera Marialbert, Kerick Martin, Lopéz-Isac Elena, Assassi Shervin, Beretta Lorenzo, Simeón-Aznar Carmen Pilar, Ortego-Centeno Norberto, Proudman Susanna M, Hunzelmann Nicolas, Moroncini Gianluca, de Vries-Bouwstra Jeska K, Orozco Gisela, Barton Anne, Herrick Ariane L, Terao Chikashi, Allanore Yannick, Brown Matthew A, Radstake Timothy Rdj, Fonseca Carmen, Denton Christopher P, Mayes Maureen D, Martin Javier

Abstract excerpt

OBJECTIVE: The greatest genetic effect reported for systemic sclerosis (SSc) lies in the major histocompatibility complex (MHC) locus. Leveraging the largest SSc genome-wide association study, we aimed to fine-map this region to identify novel human leucocyte antigen (HLA) genetic variants associated with SSc susceptibility and its main clinical and serological subtypes. METHODS: 9095 patients with SSc and 17 584...

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PMID: 34096881
DOI: 10.1136/annrheumdis-2021-219884
PMCID: PMC8292594

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Source receipt: pubmed, retrieved 7 Sept 2026.

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