Novel HLA class I and II insights into the pathogenesis of systemic sclerosis-associated interstitial lung disease.

doi:10.1016/j.ard.2026.05.004

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Article

Novel HLA class I and II insights into the pathogenesis of systemic sclerosis-associated interstitial lung disease.

Annals of the rheumatic diseases - 1 Sept 2026

Rosa-Baez Carlos, Rangel-Peláez Carlos, Rodriguez-Martin Inmaculada, Borrego-Yaniz Gonzalo, Kerick Martin, Guillen-Del-Castillo Alfredo, Simeón-Aznar Carmen P, Callejas José Luis, Voskuyl Alexandre E, Kreuter Alexander, Distler Oliver, Proudman Susanna M, Nikpour Mandana, Hunzelmann Nicholas, de Vries-Bouwstra Jeska K, Herrick Ariane L, Allanore Yannick, Beretta Lorenzo, Mayes Maureen D, Denton Christopher P, Assassi Shervin, Martín Javier, Acosta-Herrera Marialbert

Abstract excerpt

OBJECTIVES: Systemic sclerosis-associated interstitial lung disease (SSc-ILD) is the leading cause of mortality in systemic sclerosis (SSc), yet its genetic architecture remains incompletely understood. Therefore, given the key role of the major histocompatibility complex (MHC) in SSc, we aimed to perform a comprehensive MHC-wide association study in the largest SSc-ILD cohort to date. METHODS: We analysed 2412...

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Topics

Humans
Scleroderma, Systemic
Lung Diseases, Interstitial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Male

Middle Aged

Polymorphism, Single Nucleotide

Genetic Predisposition to Disease

Autoantibodies

Case-Control Studies

Genome-Wide Association Study

Histocompatibility Antigens Class I

Histocompatibility Antigens Class II

Source

Open in PubMed Open full text

Identifiers

PMID: 42218078
DOI: 10.1016/j.ard.2026.05.004
PMCID: PMC13342175

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