Article
Class II HLA associations with autoantibodies in scleroderma: a highly significant role for HLA-DP.
Genes and immunity - 1 Apr 2001
Gilchrist F C, Bunn C, Foley P J, Lympany P A, Black C M, Welsh K I, du Bois R M
Abstract excerpt
Scleroderma is a condition of variable phenotype characterised by fibrosis of the skin and internal organs. There is a range of disease-specific autoantibodies found in the sera of patients. The aims of this study were to: (1) investigate the role of the MHC and particularly HLA-DP in the production of autoantibodies; (2) investigate clinical associations with autoantibodies. We have performed HLA class II typing...
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