Immunogenetics of systemic sclerosis: Defining heritability, functional variants and shared-autoimmunity pathways.

doi:10.1016/j.jaut.2015.07.005

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Article

Immunogenetics of systemic sclerosis: Defining heritability, functional variants and shared-autoimmunity pathways.

Journal of autoimmunity - 1 Nov 2015

Bossini-Castillo Lara, López-Isac Elena, Martín Javier

Abstract excerpt

Systemic sclerosis (SSc) is a clinically heterogeneous connective tissue disorder of complex etiology. The development of large-scale genetic studies, such as genome-wide association studies (GWASs) or the Immunochip platform, has achieved remarkable progress in the knowledge of the genetic background of SSc. Herein, we provide an updated picture SSc genetic factors, offering an insight into their role in...

Topics

Animals
Autoimmunity
Genetic Loci
Genetic Predisposition to Disease
Genetic Variation
Humans
Immunogenetics
Phenotype
Polymorphism, Genetic
Risk Factors
Scleroderma, Systemic
Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 26212856
DOI: 10.1016/j.jaut.2015.07.005

Provenance

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