Article
Major histocompatibility complex (MHC) class II alleles, haplotypes and epitopes which confer susceptibility or protection in systemic sclerosis: analyses in 1300 Caucasian, African-American and Hispanic cases and 1000 controls.
Annals of the rheumatic diseases - 1 May 2010
Arnett Frank C, Gourh Pravitt, Shete Sanjay, Ahn Chul W, Honey Robert E, Agarwal Sandeep K, Tan Filemon K, McNearney Terry, Fischbach Michael, Fritzler Marvin J, Mayes Maureen D, Reveille John D
Abstract excerpt
OBJECTIVE: To determine human leucocyte antigen-class II (HLA-class II) (DRB1, DQB1, DQA1 and DPB1) alleles, haplotypes and shared epitopes associated with scleroderma (systemic sclerosis (SSc)) and its subphenotypes in a large multi-ethnic US cohort by a case-control association study. PATIENTS AND METHODS: 1300 SSc cases (961 white, 178 black and 161 Hispanic subjects) characterised for clinical skin forms...
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