Article
HLA Class I and II Blocks Are Associated to Susceptibility, Clinical Subtypes and Autoantibodies in Mexican Systemic Sclerosis (SSc) Patients.
PloS one - 1 Jan 2015
Rodriguez-Reyna Tatiana S, Mercado-Velázquez Pamela, Yu Neng, Alosco Sharon, Ohashi Marina, Lebedeva Tatiana, Cruz-Lagunas Alfredo, Núñez-Álvarez Carlos, Cabiedes-Contreras Javier, Vargas-Alarcón Gilberto, Granados Julio, Zúñiga Joaquin, Yunis Edmond
Abstract excerpt
INTRODUCTION: Human leukocyte antigen (HLA) polymorphism studies in Systemic Sclerosis (SSc) have yielded variable results. These studies need to consider the genetic admixture of the studied population. Here we used our previously reported definition of genetic admixture of Mexicans using HLA class I and II DNA blocks to map genetic susceptibility to develop SSc and its complications. METHODS: We included 159...
Topics
- Alleles
- Autoantibodies
- Black People
- Case-Control Studies
- DNA Topoisomerases
- Demography
- Disease Susceptibility
- Female
- HLA-DQ beta-Chains
- Histocompatibility Antigens Class I