Autoantibodies and scleroderma phenotype define subgroups at high-risk and low-risk for cancer.

doi:10.1136/annrheumdis-2018-212999

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Article

Autoantibodies and scleroderma phenotype define subgroups at high-risk and low-risk for cancer.

Annals of the rheumatic diseases - 1 Aug 2018

Igusa Takeru, Hummers Laura K, Visvanathan Kala, Richardson Carrie, Wigley Fredrick M, Casciola-Rosen Livia, Rosen Antony, Shah Ami A

Abstract excerpt

OBJECTIVES: Recent studies demonstrate autoantibodies are powerful tools to interrogate molecular events linking cancer and the development of autoimmunity in scleroderma. Investigating cancer risk in these biologically relevant subsets may provide an opportunity to develop personalised cancer screening guidelines. In this study, we examined cancer risk in distinct serologic and phenotypic scleroderma subsets and...

Topics

Adult
Antibodies, Antinuclear
Autoantibodies
Breast Neoplasms
Female
Humans
Incidence
Lung Neoplasms
Male
Middle Aged
Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Registries

Risk Assessment

Scleroderma, Diffuse

Scleroderma, Localized

United States

Source

Open in PubMed Open full text

Identifiers

PMID: 29678941
DOI: 10.1136/annrheumdis-2018-212999
PMCID: PMC6272061

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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