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Article

Combinations of scleroderma hallmark autoantibodies associate with distinct clinical phenotypes.

Scientific reports - 2 Jul 2022

Clark Kristina E N, Campochiaro Corrado, Host Lauren V, Sari Alper, Harvey Jennifer, Denton Christopher P, Ong Voon H

Abstract excerpt

Systemic sclerosis (SSc) is characterized by the presence of SSc-specific or SSc-associated antibodies (SSc-Abs): anti-topoisomerase I (ATA), anti-centromere (ACA), anti-RNA polymerase III (ARA), anti-U3RNP (U3RNP), anti-U1RNP (U1RNP), anti-PmScl (PmScl), anti-Ku (Ku) and anti-Th/To (Th/To), each being associated with specific clinical features and prognosis. The detection of more than one SSc-Abs in SSc patients...

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Identifiers

PMID: 35780179
DOI: 10.1038/s41598-022-15062-4
PMCID: PMC9250530

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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