Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mycobacterium tuberculosis Lipoarabinomannan Activates Human Neutrophils via a TLR2/1 Mechanism Distinct from Pam3CSK4.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2020

Hook Jessica S, Cao Mou, Weng Kayson, Kinnare Nedha, Moreland Jessica G

Abstract excerpt

Neutrophils, polymorphonuclear (PMN) leukocytes, play an important role in the early innate immune response to Mycobacterium tuberculosis infection in the lung. Interactions between PMN and mycobacterial lipids impact the activation state of these migrated cells with consequences for the surrounding tissue in terms of resolution versus ongoing inflammation. We hypothesized that lipoarabinomannan from M....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Exocytosis
Share to Lipopeptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to NADPH Oxidases

Share to Neutrophil Activation

Share to Neutrophils

Share to Toll-Like Receptor 1

Share to Toll-Like Receptor 2

Share to Tuberculosis, Pulmonary

Source

Identifiers

PMID: 31871022
DOI: 10.4049/jimmunol.1900919

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mycobacterium tuberculosis Lipoarabinomannan Activates Human Neutrophils via a TLR2/1 Mechanism Distinct from Pam3CSK4.PMID 31871022Read ↗

Exposure of Monocytes to Lipoarabinomannan Promotes Their Differentiation into Functionally and Phenotypically Immature Macrophages.Semantic proximity Read ↗

Lipoproteins from Staphylococcus aureus Drive Neutrophil Extracellular Trap Formation in a TLR2/1- and PAD-Dependent Manner.Semantic proximity Read ↗

A Common Genetic Variant in TLR1 Enhances Human Neutrophil Priming and Impacts Length of Intensive Care Stay in Pediatric Sepsis.Semantic proximity Read ↗

Neutrophils in multiple sclerosis are characterized by a primed phenotype.Semantic proximity Read ↗

CD1-Restricted T Cell Recognition of Microbial Lipoglycan AntigensSemantic proximity Read ↗

Activation of Human Toll-like Receptor 4 (TLR4)·Myeloid Differentiation Factor 2 (MD-2) by Hypoacylated Lipopolysaccharide from a Clinical Isolate of Burkholderia cenocepaciaSemantic proximity Read ↗

Multiple Phenotypic Changes Define Neutrophil Priming.Semantic proximity Read ↗

Intermediate maturation of Mycobacterium tuberculosis LAM-activated human dendritic cells.Semantic proximity Read ↗

Complement activation by ligand-driven juxtaposition of discrete pattern recognition complexesSemantic proximity Read ↗

Human TLR4 and noncanonical inflammasome differ in their ability to respond to distinct lipid A variantsSemantic proximity Read ↗

LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis.Semantic proximity Read ↗

TLR1- and TLR6-independent Recognition of Bacterial LipopeptidesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.