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Article

TLR1- and TLR6-independent Recognition of Bacterial Lipopeptides

3 Feb 2006

Abstract excerpt

Bacterial cell walls contain lipoproteins/peptides, which are strong modulators of the innate immune system. Triacylated lipopeptides are assumed to be recognized by TLR2/TLR1-, whereas diacylated lipopeptides use TLR2/TLR6 heteromers for signaling. Following our initial discovery of TLR6-independent diacylated lipopeptides, we could now characterize di- and triacylated lipopeptides (e.g. Pam(2)C-SK(4),...

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PMID: 16455646
DOI: 10.1074/jbc.m512525200

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