Article

Human TLR4 and noncanonical inflammasome differ in their ability to respond to distinct lipid A variants

2021-12-16

Abstract excerpt

Detection of Gram-negative bacterial lipid A by the extracellular sensor, MD-2/TLR4 or the intracellular inflammasome sensors, CASP4 and CASP5, induces robust inflammatory responses. The chemical structure of lipid A, specifically the phosphorylation and acylation state, varies across and within bacterial species, potentially allowing pathogens to evade or suppress host immunity. Currently, it is not clear how dis...

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Literature Corpus work: 80e9d628-3067-5522-bf56-2e72bca6466c
DOI: 10.1101/2021.12.16.472937

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