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Article

LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis.

PLoS pathogens - 1 Sept 2014

Gaur Rajiv L, Ren Kangning, Blumenthal Antje, Bhamidi Suresh, González-Nilo Fernando D, Gibbs Sara, Jackson Mary, Zare Richard N, Ehrt Sabine, Ernst Joel D, Banaei Niaz

Abstract excerpt

Mycobacterium tuberculosis employs various virulence strategies to subvert host immune responses in order to persist and cause disease. Interaction of M. tuberculosis with mannose receptor on macrophages via surface-exposed lipoarabinomannan (LAM) is believed to be critical for cell entry, inhibition of phagosome-lysosome fusion, and intracellular survival, but in vivo evidence is lacking. LprG, a cell envelope...

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Identifiers

PMID: 25232742
DOI: 10.1371/journal.ppat.1004376
PMCID: PMC4169494

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis.PMID 25232742Read ↗

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