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Complement activation by ligand-driven juxtaposition of discrete pattern recognition complexes

2 Sept 2014

Abstract excerpt

Defining mechanisms governing translation of molecular binding events into immune activation is central to understanding immune function. In the lectin pathway of complement, the pattern recognition molecules (PRMs) mannan-binding lectin (MBL) and ficolins complexed with the MBL-associated serine proteases (MASP)-1 and MASP-2 cleave C4 and C2 to generate C3 convertase. MASP-1 was recently found to be the...

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PMID: 25197071
DOI: 10.1073/pnas.1406849111

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