Neutrophils in multiple sclerosis are characterized by a primed phenotype.

Abstract excerpt

Neutrophils are armed with proteases with indiscriminate histotoxic potential, and to minimize tissue injury, their activation involves priming with inflammatory mediators before cells are fully activated in a second step. Here, we show that neutrophils in multiple sclerosis patients are more numerous and exhibit a primed state based on reduced apoptosis, higher expression of TLR-2, fMLP receptor, IL-8 receptor...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Apoptosis
• Share to Biomarkers
• Share to Cell Degranulation