Article
Intermediate maturation of Mycobacterium tuberculosis LAM-activated human dendritic cells.
Cellular microbiology - 1 Jun 2007
Dulphy Nicolas, Herrmann Jean-Louis, Nigou Jérôme, Réa Delphine, Boissel Nicolas, Puzo Germain, Charron Dominique, Lagrange Philippe H, Toubert Antoine
Abstract excerpt
Contrasting observations raise the question of the role of mycobacterial derived products as compared with the whole bacterium Mycobacterium tuberculosis on maturation and function of human dendritic cells (DCs). DC-SIGN has been identified as the key DC receptor for M. tuberculosis through its interaction with the mannosylated lipoarabinomannan (ManLAM). Although ManLAM is a major mycobacterial component...
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