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Article

A Common Genetic Variant in TLR1 Enhances Human Neutrophil Priming and Impacts Length of Intensive Care Stay in Pediatric Sepsis.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2016

Whitmore Laura C, Hook Jessica S, Philiph Amanda R, Hilkin Brieanna M, Bing Xinyu, Ahn Chul, Wong Hector R, Ferguson Polly J, Moreland Jessica G

Abstract excerpt

Polymorphonuclear leukocytes (PMN) achieve an intermediate or primed state of activation following stimulation with certain agonists. Primed PMN have enhanced responsiveness to subsequent stimuli, which can be beneficial in eliminating microbes but may cause host tissue damage in certain disease contexts, including sepsis. As PMN priming by TLR4 agonists is well described, we hypothesized that ligation of TLR2/1...

Topics

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Enzyme-Linked Immunosorbent Assay
Immunoblotting
Intensive Care Units
Length of Stay
Neutrophil Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Toll-Like Receptor 1

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Open in PubMed Open full text

Identifiers

PMID: 26729809
DOI: 10.4049/jimmunol.1500856
PMCID: PMC4724530

Genes

TLR1
TLR2
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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