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Article

Lipoproteins from Staphylococcus aureus Drive Neutrophil Extracellular Trap Formation in a TLR2/1- and PAD-Dependent Manner.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2021

Hook Jessica S, Patel Parth A, O'Malley Aidan, Xie Lihua, Kavanaugh Jeffrey S, Horswill Alexander R, Moreland Jessica G

Abstract excerpt

Neutrophils, polymorphonuclear leukocytes (PMN), play a critical role in the innate immune response to Staphylococcus aureus, a pathogen that continues to be associated with significant morbidity and mortality. Neutrophil extracellular trap (NET) formation is involved in ensnaring and killing of S. aureus, but this host-pathogen interaction also leads to host tissue damage. Importantly, NET components including...

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Identifiers

PMID: 34290104
DOI: 10.4049/jimmunol.2100283
PMCID: PMC8324556

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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