Article
Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition.
PLoS biology - 1 Dec 2019
Kettunen Johannes, Holmes Michael V, Allara Elias, Anufrieva Olga, Ohukainen Pauli, Oliver-Williams Clare, Wang Qin, Tillin Therese, Hughes Alun D, Kähönen Mika, Lehtimäki Terho, Viikari Jorma, Raitakari Olli T, Salomaa Veikko, Järvelin Marjo-Riitta, Perola Markus, Davey Smith George, Chaturvedi Nish, Danesh John, Di Angelantonio Emanuele, Butterworth Adam S, Ala-Korpela Mika
Abstract excerpt
Cholesteryl ester transfer protein (CETP) inhibition reduces vascular event risk, but confusion surrounds its effects on low-density lipoprotein (LDL) cholesterol. Here, we clarify associations of genetic inhibition of CETP on detailed lipoprotein measures and compare those to genetic inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR). We used an allele associated with lower CETP expression...
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