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Precision Regulation of LDL Metabolism: Epigenetic and Genetic Approaches Targeting LDLR, APOB, and PCSK9

2025-08-04

Abstract excerpt

Low-density lipoprotein cholesterol (LDL-C) is a major risk factor for atherosclerotic cardiovascular diseases (ASCVD), and its regulation is a central goal in lipid-lowering therapies. Key genes involved in LDL metabolism-LDLR, APOB, and PCSK9-have emerged as crucial molecular targets for precision interventions. This review explores current epigenetic and genetic strategies for modulating the expression and acti...

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Literature Corpus work
975fddc3-daec-5b51-8dbd-10d59528ea91
DOI
10.22541/au.175433582.22834189/v1
Open publication

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