Article
Cholesteryl ester transfer protein polymorphisms, statin use, and their impact on cholesterol levels and cardiovascular events.
Clinical pharmacology and therapeutics - 1 Mar 2014
Leusink M, Onland-Moret N C, Asselbergs F W, Ding B, Kotti S, van Zuydam N R, Papp A C, Danchin N, Donnelly L, Morris A D, Chasman D I, Doevendans P A F M, Klungel O H, Ridker P M, van Gilst W H, Simon T, Nyberg F, Palmer C N A, Sadee W, van der Harst P, de Bakker P I W, de Boer A, Verstuyft C, Maitland-van der Zee A H
Abstract excerpt
The association of nonfunctional variants of the cholesteryl ester transfer protein (CETP) with efficacy of statins has been a subject of debate. We evaluated whether three functional CETP variants influence statin efficacy. The effect of CETP genotype on achieved levels of high-density lipoprotein cholesterol (HDLc), low-density lipoprotein cholesterol (LDLc), and total cholesterol during statin treatment was...
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