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Article

Association of Genetic Variants Related to CETP Inhibitors and Statins With Lipoprotein Levels and Cardiovascular Risk.

JAMA - 12 Sept 2017

Ference Brian A, Kastelein John J P, Ginsberg Henry N, Chapman M John, Nicholls Stephen J, Ray Kausik K, Packard Chris J, Laufs Ulrich, Brook Robert D, Oliver-Williams Clare, Butterworth Adam S, Danesh John, Smith George Davey, Catapano Alberico L, Sabatine Marc S

Abstract excerpt

Importance: Some cholesteryl ester transfer protein (CETP) inhibitors lower low-density lipoprotein cholesterol (LDL-C) levels without reducing cardiovascular events, suggesting that the clinical benefit of lowering LDL-C may depend on how LDL-C is lowered. Objective: To estimate the association between changes in levels of LDL-C (and other lipoproteins) and the risk of cardiovascular events related to variants...

Read the complete abstract on PubMed

Topics

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Share to Anticholesteremic Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholesterol Ester Transfer Proteins

Share to Cholesterol, HDL

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Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors

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Source

Open in PubMed Open full text

Identifiers

PMID: 28846118
DOI: 10.1001/jama.2017.11467
PMCID: PMC5710502

Genes

CETP
HMGCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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