Article

CETP inhibition Reduces Cardiovascular Events by Lowering of Cumulative LDL Exposure: Reconciling Evidence from Human Genetics and Clinical Trials

2024-12-03

Abstract excerpt

<h4>Background</h4> Genetic studies consistently demonstrate that individuals born with reduced Cholesteryl Ester Transfer Protein (CETP) activity experience lower rates of atherosclerotic vascular disease throughout their lives. In contrast, short-term randomized controlled trials of CETP inhibitors have yielded mixed results, with only one of four trials reporting a reduction in clinical events. Several theories...

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Literature Corpus work: 32e7e309-c3ac-5b68-bc6a-9e82b5177c16
DOI: 10.1101/2024.12.02.24318306

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