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Article

Genetic inhibition of CETP, ischemic vascular disease and mortality, and possible adverse effects.

Journal of the American College of Cardiology - 13 Nov 2012

Johannsen Trine Holm, Frikke-Schmidt Ruth, Schou Jesper, Nordestgaard Børge G, Tybjærg-Hansen Anne

Abstract excerpt

OBJECTIVES: This study tested whether genetic variation in the CETP gene is consistent with a protective effect of cholesteryl ester transfer protein (CETP) inhibition on risk of ischemic events and on total mortality, without the adverse effects reported for torcetrapib. BACKGROUND: Torcetrapib, an inhibitor of CETP, increased risk of death and ischemic cardiovascular disease of those randomized to the drug,...

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Source

Identifiers

PMID: 23083790
DOI: 10.1016/j.jacc.2012.07.045

Genes

CETP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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