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Establishment of infectious genotype 4 cell culture-derived hepatitis C virus.

The Journal of general virology - 1 Feb 2020

Watanabe Noriyuki, Suzuki Takaya, Date Tomoko, Hussan Hussein Aly, Hmwe Su Su, Aizaki Hideki, Sugiyama Masaya, Mizokami Masashi, Delaney Iv William, Cheng Guofeng, Muramatsu Masamichi, Wakita Takaji

Abstract excerpt

To establish infectious genotype 4a (GT4a) cell culture-derived hepatitis C virus (HCVcc), we constructed full-length ED43 and 12 mutants possessing single or double mutations that increase ED43 replicon replication, and performed cell culture after RNA transfection. Sequential long-term culture of full-length ED43 RNA-transfected cells showed increased viral production in two ED43 mutants named ED43 QK/SI and...

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Antibodies, Neutralizing
Antiviral Agents
Cell Culture Techniques
Hepatitis C
Replicon

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Viral Nonstructural Proteins

Virus Replication

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PMID: 31859613
DOI: 10.1099/jgv.0.001378

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