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Article

Efficient replication of genotype 3a and 4a hepatitis C virus replicons in human hepatoma cells.

Antimicrobial agents and chemotherapy - 1 Oct 2012

Saeed Mohsan, Scheel Troels K H, Gottwein Judith M, Marukian Svetlana, Dustin Lynn B, Bukh Jens, Rice Charles M

Abstract excerpt

Despite recent advances in the treatment of hepatitis C, the quest for pan-genotype, effective, and well-tolerated inhibitors continues. To facilitate these efforts, it is desirable to have in vitro replication systems for all major HCV genotypes. However, cell culture replication systems exist for only genotypes 1a, 1b, and 2a. In this study, we generated G418-selectable subgenomic replicons for prototype...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22869572
DOI: 10.1128/AAC.01256-12
PMCID: PMC3457365

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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