Article
A Hepatitis C virus genotype 1b post-transplant isolate with high replication efficiency in cell culture and its adaptation to infectious virus production in vitro and in vivo.
PLoS pathogens - 1 Jun 2022
Heuss Christian, Rothhaar Paul, Burm Rani, Lee Ji-Young, Ralfs Philipp, Haselmann Uta, Ströh Luisa J, Colasanti Ombretta, Tran Cong Si, Schäfer Noemi, Schnitzler Paul, Merle Uta, Bartenschlager Ralf, Patel Arvind H, Graw Frederik, Krey Thomas, Laketa Vibor, Meuleman Philip, Lohmann Volker
Abstract excerpt
Hepatitis C virus (HCV) is highly diverse and grouped into eight genotypes (gts). Infectious cell culture models are limited to a few subtypes and isolates, hampering the development of prophylactic vaccines. A consensus gt1b genome (termed GLT1) was generated from an HCV infected liver-transplanted patient. GLT1 replicated to an outstanding efficiency in Huh7 cells upon SEC14L2 expression, by use of replication...
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