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Article

Establishment of robust HCV genotype 4d, 5a, and 6a replicon systems.

Virology - 15 Jan 2018

Camus Gregory, Xu Simin, Han Bin, Lu Julia, Dvory-Sobol Hadas, Yu Mei, Cheng Guofeng, Miller Michael D, Doehle Brian P, Mo Hongmei

Abstract excerpt

Hepatitis C Virus (HCV) is a diverse human pathogen which displays ~15% divergence at the subtype level. To facilitate development of antivirals with pan-genotype activity, we developed the first genotype 4d subgenomic replicon, as well as new replicons for genotypes 5a, and 6a. Adaptive mutations developed in these replicons differ greatly across genotypes. Their impacts on the replication capacity were tested...

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Identifiers

PMID: 29175627
DOI: 10.1016/j.virol.2017.11.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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