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Article

Replication of hepatitis C virus genotype 3a in cultured cells.

Gastroenterology - 1 Jan 2013

Saeed Mohsan, Gondeau Claire, Hmwe Susu, Yokokawa Hiroshi, Date Tomoko, Suzuki Tetsuro, Kato Takanobu, Maurel Patrick, Wakita Takaji

Abstract excerpt

Hepatitis C virus (HCV) genotype 3a is widespread worldwide, but no replication system exists for its study. We describe a subgenomic replicon system for HCV genotype 3a. We determined the consensus sequence of an HCV genome isolated from a patient, and constructed a subgenomic replicon using this clone. The replicon was transfected into HuH-7 cells and RNA replication was confirmed. We identified cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22999961
DOI: 10.1053/j.gastro.2012.09.017

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