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Article

Novel HCV Genotype 4d Infectious Systems and Assessment of Direct-Acting Antivirals and Antibody Neutralization.

Viruses - 15 Nov 2022

Pham Long V, Velázquez-Moctezuma Rodrigo, Fahnøe Ulrik, Collignon Laura, Bajpai Priyanka, Sølund Christina, Weis Nina, Holmbeck Kenn, Prentoe Jannick, Bukh Jens

Abstract excerpt

Hepatitis C virus (HCV) genotype 4 is highly prevalent in the Middle East and parts of Africa. Subtype 4d has recently spread among high-risk groups in Europe. However, 4d infectious culture systems are not available, hampering studies of drugs, as well as neutralizing antibodies relevant for HCV vaccine development. We determined the consensus 4d sequence from a chronic hepatitis C patient by next-generation...

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Identifiers

PMID: 36423136
DOI: 10.3390/v14112527
PMCID: PMC9698709

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