Article
Robust and persistent replication of the genotype 6a hepatitis C virus replicon in cell culture.
Antimicrobial agents and chemotherapy - 1 May 2014
Yu Mei, Peng Betty, Chan Katie, Gong Ruoyu, Yang Huiling, Delaney William, Cheng Guofeng
Abstract excerpt
Genotype 6 (GT6) hepatitis C virus (HCV) is prevalent in Southeast Asia and southern China, where it can constitute up to 50% of HCV infections. Despite this, no direct-acting antivirals are approved to treat GT6 HCV infection, and no cell culture systems have been described. In this study, we aimed to develop a GT6 HCV subgenomic replicon to facilitate the identification and development of new HCV therapies with...
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