Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Efficient infectious cell culture systems of the hepatitis C virus (HCV) prototype strains HCV-1 and H77.

Journal of virology - 1 Jan 2015

Li Yi-Ping, Ramirez Santseharay, Mikkelsen Lotte, Bukh Jens

Abstract excerpt

UNLABELLED: The first discovered and sequenced hepatitis C virus (HCV) genome and the first in vivo infectious HCV clones originated from the HCV prototype strains HCV-1 and H77, respectively, both widely used in research of this important human pathogen. In the present study, we developed efficient infectious cell culture systems for these genotype 1a strains by using the HCV-1/SF9_A and H77C in vivo infectious...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Biological
Share to Genes, Viral
Share to Hepatocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Viral Load

Share to Virus Cultivation

Share to Virus Internalization

Share to Virus Release

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 25355880
DOI: 10.1128/JVI.02877-14
PMCID: PMC4301150

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Efficient infectious cell culture systems of the hepatitis C virus (HCV) prototype strains HCV-1 and H77.PMID 25355880Read ↗

Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system.Semantic proximity Read ↗

Current status and future development of infectious cell-culture models for the major genotypes of hepatitis C virus: Essential tools in testing of antivirals and emerging vaccine strategies.Semantic proximity Read ↗

Efficient Hepatitis C Virus Genotype 1b Core-NS5A Recombinants Permit Efficacy Testing of Protease and NS5A InhibitorsSemantic proximity Read ↗

Efficient culture adaptation of hepatitis C virus recombinants with genotype-specific core-NS2 by using previously identified mutations.Semantic proximity Read ↗

Development of cell culture infectious clones for hepatitis C virus genotype 1b and transcription analysis of 1b-infected hepatoma cells.Semantic proximity Read ↗

Production of infectious hepatitis C virus of various genotypes in cell cultures.Semantic proximity Read ↗

Robust hepatitis C genotype 3a cell culture releasing adapted intergenotypic 3a/2a (S52/JFH1) viruses.Semantic proximity Read ↗

Identification of nucleotides in the 5'UTR and amino acids substitutions that are essential for the infectivity of 5'UTR-NS5A recombinant of hepatitis C virus genotype 1b (strain Con1).Semantic proximity Read ↗

A novel strategy to develop a robust infectious hepatitis C virus cell culture system directly from a clinical isolate.Semantic proximity Read ↗

Generation of a cell culture-adapted hepatitis C virus with longer half life at physiological temperature.Semantic proximity Read ↗

Adaptive Mutations Enhance Assembly and Cell-to-Cell Transmission of a High-Titer Hepatitis C Virus Genotype 5a Core-NS2 JFH1-Based Recombinant.Semantic proximity Read ↗

Novel mutations in a tissue culture-adapted hepatitis C virus strain improve infectious-virus stability and markedly enhance infection kinetics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.