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Article

Hepatitis C virus genotype 5a subgenomic replicons for evaluation of direct-acting antiviral agents.

Antimicrobial agents and chemotherapy - 1 Sept 2014

Wose Kinge Constance N, Espiritu Christine, Prabdial-Sing Nishi, Sithebe Nomathamsaqa Patricia, Saeed Mohsan, Rice Charles M

Abstract excerpt

Hepatitis C virus (HCV) exists as six major genotypes that differ in geographical distribution, pathogenesis, and response to antiviral therapy. In vitro replication systems for all HCV genotypes except genotype 5 have been reported. In this study, we recovered genotype 5a full-length genomes from four infected voluntary blood donors in South Africa and established a G418-selectable subgenomic replicon system...

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Identifiers

PMID: 24982066
DOI: 10.1128/AAC.03534-14
PMCID: PMC4135880

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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