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Article

Development of full-length cell-culture infectious clone and subgenomic replicon for a genotype 3a isolate of hepatitis C virus.

The Journal of general virology - 1 Dec 2021

Chen Mingxiao, Xu Yi, Li Ni, Yin Ping, Zhou Qing, Feng Shengjun, Wu Tiantian, Wei Lai, Wang Haihe, Fu Yongshui, Li Yi-Ping

Abstract excerpt

Hepatitis C virus (HCV) genotype 3 is widely distributed, and genotype 3-infected patients achieve a lower cure rate in direct-acting antiviral (DAA) therapy and are associated with a higher risk of hepatic steatosis than patients with other genotypes. Thus, the study of the virology and pathogenesis of genotype 3 HCV is increasingly relevant. Here, we developed a full-length infectious clone and a subgenomic...

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PMID: 34949310
DOI: 10.1099/jgv.0.001704

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