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Article

Insights into the unique characteristics of hepatitis C virus genotype 3 revealed by development of a robust sub-genomic DBN3a replicon.

The Journal of general virology - 1 Nov 2020

Ward Joseph C, Bowyer Sebastian, Chen Shucheng, Fernandes Campos Guilherme Rodrigues, Ramirez Santseharay, Bukh Jens, Harris Mark

Abstract excerpt

Hepatitis C virus (HCV) is an important human pathogen causing 400 000 chronic liver disease-related deaths annually. Until recently, the majority of laboratory-based investigations into the biology of HCV have focused on the genotype 2 isolate, JFH-1, involving replicons and infectious cell culture systems. However, genotype 2 is one of eight major genotypes of HCV and there is great sequence variation among...

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Identifiers

PMID: 32897181
DOI: 10.1099/jgv.0.001486
PMCID: PMC7879556

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