Article

Pathogenic mitochondrial DNA mutations inhibit melanoma metastasis

2023-09-05

Abstract excerpt

Mitochondrial DNA (mtDNA) mutations are frequently observed in cancer, but their contribution to tumor progression is controversial. To evaluate the impact of mtDNA variants on tumor growth and metastasis, we created human melanoma cytoplasmic hybrid (cybrid) cell lines transplanted with wildtype mtDNA or pathogenic mtDNA encoding variants that partially or completely inhibit oxidative phosphorylation. Homoplasmic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ebb3778d-1d08-54be-af4e-6379e66015e2
DOI: 10.1101/2023.09.01.555986

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pathogenic mitochondrial DNA mutations inhibit melanoma metastasisDOI 10.1101/2023.09.01.555986Read

Pathogenic mitochondrial DNA mutations inhibit melanoma metastasis.Semantic proximity Read

Trading mtDNA uncovers its role in metastasis.Semantic proximity Read

Mitochondrial DNA polymorphisms and biogenesis genes in primary and metastatic uveal melanoma cell lines.Semantic proximity Read

ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis.Semantic proximity Read

Mitochondrial dysfunction and immune suppression in BRAF V600E-mutated metastatic melanoma.Semantic proximity Read

Mitochondrial DNA mutation enhances sensitivity to immunotherapy in melanoma.Semantic proximity Read

Mitochondrial DNA in Tumor Initiation, Progression, and Metastasis: Role of Horizontal mtDNA Transfer.Semantic proximity Read

Patient-derived zebrafish xenografts of uveal melanoma reveal ferroptosis as a drug targetSemantic proximity Read

Mitochondrial Haplotype of the Host Stromal Microenvironment Alters Metastasis in a Non-cell Autonomous Manner.Semantic proximity Read

Mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade response in melanoma.Semantic proximity Read

Intercellular transfer of mitochondrial DNA carrying metastasis-enhancing pathogenic mutations from high- to low-metastatic tumor cells and stromal cells via extracellular vesicles.Semantic proximity Read

Patient-derived zebrafish xenografts of uveal melanoma reveal ferroptosis as a drug targetSemantic proximity Read